Epoxy resin is heavy, so if your painting is large or if you're using a lot of epoxy resin, normal picture frame wire is not going to be strong enough to support your artwork. Instead, try hanging heavy artwork using aircraft cable, a thin, flexible but exceptionally strong steel cable found at hardware stores.
Another highly effective method for hanging heavy artwork is to use two pieces of wood that have complimentary 45 degree angles cut into them. One block of wood is installed securely into the wall, and the other block of wood is installed onto the back of the painting. When that painting is hung, the 45 degree angles lock together, securing your artwork in place.